SHP2-IN-35

MedChem Express

SHP2-IN-35

5

Research Use Only

C34H32FeO6

592.46

SHP2-IN-35 (Compound 3f) is the inhibitor for SHP2. SHP2-IN-35 exhibits antiproliferative activity in cancer cells RKO, SW480 and CT26 with IC50 of 5.72 microM, 3.71 microM and 1.42 microM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the cell cycle associated gene expressions, and induces mitochondrial-related autophagy. SHP2-IN-35 inhibits the expression of certain cytokines and chemokines in the tumor microenvironment (TME), thereby regulating the tumor progression[1].

O=C(/C=C/C1=CC=C(OC)C(OC)=C1)/C(C(/C=C/C2=CC=C(OC)C(OC)=C2)=O)=C/c3cccc3.[][Fe][].c4cccc4

12352200