SHP2-IN-38

MedChem Express

SHP2-IN-38

999

Research Use Only

C20H15N3O3S

377.42

SHP2-IN-38 is a novel green-fluorescent SHP2 inhibitor with IC50 values of 2.89 microM (SHP2), 8.73 microM (SHP1), 11.08 microM (PTP1B), 33.07 microM (TCPTP). SHP2-IN-38 blocks the SHP2-mediated ERK signaling pathway and inhibits MV4-11 cells proliferation in vitro with IC50 of 7.90 microM. SHP2-IN-38 has an excitation wavelength of 360 nm, with a maximum emission wavelength of 550 nm in DMSO and 540 nm in DMF. SHP2-IN-38 shows green fluorescence imaging in HeLa cells and zebrafish[1].

OC1=C(C(O)=O)C=C(C2=CN(N=C(/C=C/C3=CC=C(C)C=C3)S4)C4=N2)C=C1

12352200