SHP2-IN-8 [1801692-60-3]
HY-144396
CAS Number1801692-60-3
Product group Chemicals
Molecular Weight398.35
Overview
- SupplierMedChem Express
- Product NameSHP2-IN-8 [1801692-60-3]
- Delivery Days Customer10
- CAS Number1801692-60-3
- CertificationResearch Use Only
- Molecular FormulaC17H21Cl2N5S
- Molecular Weight398.35
- Scientific DescriptionSHP2-IN-8 is a highly potent, selective, and cellularly active allosteric SHP2 inhibitor with IC50 value of 23 nM and Ki of 22 nM. SHP2-IN-8 is reversible and noncompetitive. SHP2-IN-8 causes a significant thermal shift with the deltaTm of 7.01 °C. SHP2-IN-8 induces the apoptosis and inhibits the phosphorylation of AKT in Hela cells[1].
- SMILESNC1=NC(N2CCC(C)(CN)CC2)=CN=C1SC3=CC=CC(Cl)=C3Cl
- UNSPSC12352200