SIAIS164018 [2353492-68-7]
HY-147219
Overview
- SupplierMedChem Express
- Product NameSIAIS164018 [2353492-68-7]
- Delivery Days Customer10
- CAS Number2353492-68-7
- CertificationResearch Use Only
- Molecular FormulaC43H48ClN10O7P
- Molecular Weight883.33
- Scientific DescriptionSIAIS164018 is a PROTAC-based ALK and EGFR degrader, with IC50 value of 2.5 nM and 6.6 nM for ALK and ALK G1202R, respectively. SIAIS164018 strongly inhibits cancer cells migration and invasion, causes G1 cell cycle arrest and induces apoptosis. SIAIS164018 exhibits better property than Brigatinib (HY-12857)[1].
- SMILESO=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCC(N4CCN(C5CCN(CC5)C6=CC=C(C(OC)=C6)NC7=NC=C(C(NC8=C(P(C)(C)=O)C=CC=C8)=N7)Cl)CC4)=O)=CC=C3)=O)=O
- UNSPSC12131703