Bio-Connect

SIAIS164018 [2353492-68-7]

HY-147219
MedChem Express
CAS Number2353492-68-7
Product group Chemicals
Molecular Weight883.33
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Overview

  • Supplier
    MedChem Express
  • Product Name
    SIAIS164018 [2353492-68-7]
  • Delivery Days Customer
    10
  • CAS Number
    2353492-68-7
  • Certification
    Research Use Only
  • Molecular Formula
    C43H48ClN10O7P
  • Molecular Weight
    883.33
  • Scientific Description
    SIAIS164018 is a PROTAC-based ALK and EGFR degrader, with IC50 value of 2.5 nM and 6.6 nM for ALK and ALK G1202R, respectively. SIAIS164018 strongly inhibits cancer cells migration and invasion, causes G1 cell cycle arrest and induces apoptosis. SIAIS164018 exhibits better property than Brigatinib (HY-12857)[1].
  • SMILES
    O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCC(N4CCN(C5CCN(CC5)C6=CC=C(C(OC)=C6)NC7=NC=C(C(NC8=C(P(C)(C)=O)C=CC=C8)=N7)Cl)CC4)=O)=CC=C3)=O)=O
  • UNSPSC
    12131703