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Siamycin I [164802-68-0]

Siamycin I [164802-68-0]

T37468
TargetMol Chemicals
CAS Number164802-68-0
Product group Chemicals
Molecular Weight2163.49
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Siamycin I [164802-68-0]
  • Delivery Days Customer
    44
  • CAS Number
    164802-68-0
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    Siamycin I
  • Molecular Formula
    C97H131N23O26S4
  • Molecular Weight
    2163.49
  • Scientific Description
    Siamycin I is a tricyclic peptide originally isolated from Streptomyces and has antiviral and antibacterial activities. It is active against laboratory strains and clinical isolates of HIV-1 (ED50s = 0.05-0.45 and 0.89-5.7 microM, respectively), as well as the CBL-20 strain of HIV-2 (ED50 = 0.45 microM), in vitro. Siamycin I inhibits HIV-induced fusion of C8166 T cells with HIV-1-infected CEM-SS cells with an ED50 value of 0.08 microM. It is also active against B. subtilis, M. luteus, and S. aureus (MICs = 1.6-6.3 microg/ml). Siamycin I inhibits autophosphorylation of the E. faecalis quorum sensing kinase FsrC induced by gelatinase biosynthesis-activating pheromone (GBAP).
  • Shelf life instruction
    3 years
  • SMILES
    [H][C@]12CSSC[C@]3([H])NC(=O)C[C@]([H])(NC(=O)[C@H](CC(N)=O)NC(=O)[C@]([H])(CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@]([H])(NC(=O)[C@H](C)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)CNC1=O)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)C(NC(=O)CNC(=O)[C@H](CC(C)C)NC3=O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)NCC(=O)N2 - @:129 -
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200