![Siamycin I [164802-68-0] Siamycin I [164802-68-0]](https://www.targetmol.com/group3/M00/02/E4/CgoaEWY7O3-EfbsvAAAAAECJh7o745.png)
Siamycin I [164802-68-0]
T37468
Overview
- SupplierTargetMol Chemicals
- Product NameSiamycin I [164802-68-0]
- Delivery Days Customer44
- CAS Number164802-68-0
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameSiamycin I
- Molecular FormulaC97H131N23O26S4
- Molecular Weight2163.49
- Scientific DescriptionSiamycin I is a tricyclic peptide originally isolated from Streptomyces and has antiviral and antibacterial activities. It is active against laboratory strains and clinical isolates of HIV-1 (ED50s = 0.05-0.45 and 0.89-5.7 microM, respectively), as well as the CBL-20 strain of HIV-2 (ED50 = 0.45 microM), in vitro. Siamycin I inhibits HIV-induced fusion of C8166 T cells with HIV-1-infected CEM-SS cells with an ED50 value of 0.08 microM. It is also active against B. subtilis, M. luteus, and S. aureus (MICs = 1.6-6.3 microg/ml). Siamycin I inhibits autophosphorylation of the E. faecalis quorum sensing kinase FsrC induced by gelatinase biosynthesis-activating pheromone (GBAP).
- Shelf life instruction3 years
- SMILES[H][C@]12CSSC[C@]3([H])NC(=O)C[C@]([H])(NC(=O)[C@H](CC(N)=O)NC(=O)[C@]([H])(CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@]([H])(NC(=O)[C@H](C)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)CNC1=O)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)C(NC(=O)CNC(=O)[C@H](CC(C)C)NC3=O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)NCC(=O)N2 - @:129 -
- Storage Instruction-20°C
- UNSPSC12352200