Sibiriline

MedChem Express

Sibiriline [1346526-26-8]

5

1346526-26-8

Research Use Only

C13H10N2O

210.23

Sibiriline is a specific competitive inhibitor of RIPK1 that targets the RIPK1 ATP-binding site and locks it in an inactive conformation. Sibiriline inhibits TNF-induced RIPK1 -dependent necroptosis and RIPK1 -dependent apoptosis, but does not protect cells from caspase-dependent apoptosis. Sibiriline protects mice from concanavalin A-induced hepatitis and has the potential to inhibit immune-dependent hepatitis. [1] .

OC1=CC=C(C=C1)C2=CC3=CC=CN=C3N2

12352200