Sibiriline [1346526-26-8]
HY-120600
CAS Number1346526-26-8
Product group Chemicals
Molecular Weight210.23
Overview
- SupplierMedChem Express
- Product NameSibiriline [1346526-26-8]
- Delivery Days Customer5
- CAS Number1346526-26-8
- CertificationResearch Use Only
- Molecular FormulaC13H10N2O
- Molecular Weight210.23
- Scientific DescriptionSibiriline is a specific competitive inhibitor of RIPK1 that targets the RIPK1 ATP-binding site and locks it in an inactive conformation. Sibiriline inhibits TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis, but does not protect cells from caspase-dependent apoptosis. Sibiriline protects mice from concanavalin A-induced hepatitis and has the potential to inhibit immune-dependent hepatitis.[1].
- SMILESOC1=CC=C(C=C1)C2=CC3=CC=CN=C3N2
- UNSPSC12352200
MSDS
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