SIGIRR (human):Fc (human) (rec.)

AdipoGen Life Sciences

SIGIRR (human):Fc (human) (rec.)

10

Research Use Only

>90%

Protein. Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG1. Source: HEK 293 cells. Endotoxin content: <0.06EU/microg purified protein (LAL test; Lonza). Lyophilized from 0.2microm-filtered solution in PBS. Purity: >90% (SDS-PAGE). SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. - SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4.

-20°C,2°C to 8°C

12352202