Sigma-1 receptor antagonist 5

MedChem Express

Sigma-1 receptor antagonist 5 [2952808-33-0]

14

Research Use Only

C26H27N3O

397.51

Sigma-1 receptor antagonist 5 (compound 12), a 4-pyridylpiperidine derivative with analgesic activity, is an antagonist of sigma receptor (Ki=4.5 nM (sigma1R), 10 nM (sigma2R)) and histamine H3 (hH3R, Ki=7.7 nM, IC50=215 nM). Sigma-1 receptor antagonist 5 suppresses Capsaicin-induced nociception with antinociceptive activity and shows potent efficacy in nociceptive and neuropathic pain models[1].

N#CC1=CC=C(C2=CC=C(OCCCN3CCC(C4=CC=NC=C4)CC3)C=C2)C=C1

12131703