SIJ1777

Biorbyt

SIJ1777

10

Research Use Only

98.00%

C26H23F3N8O2

536.51

SIJ1777, a derivative of GNF-7, exhibits potent anticancer effects against melanoma cells harboring BRAFI/II/III mutations. The compound significantly inhibits the activation of MEK, ERK, and AKT. Furthermore, SIJ1777 notably induces apoptosis (cell death) and effectively prevents migration, invasion, and anchorage-independent growth of melanoma cells with BRAFI/II/III mutations.

O=C(NC1=CC=C(C(=C1)N2C(=O)N(C3=NC(=NC=C3C2)NC4=NN(C=C4)C)C)C)C5=CC=CC(=C5)C(F)(F)F

-20°C

12352200