SIKs-IN-1 [2927557-06-8]
HY-149365
CAS Number2927557-06-8
Product group Chemicals
Molecular Weight507.58
Overview
- SupplierMedChem Express
- Product NameSIKs-IN-1 [2927557-06-8]
- Delivery Days Customer14
- CAS Number2927557-06-8
- CertificationResearch Use Only
- Molecular FormulaC27H31F2N7O
- Molecular Weight507.58
- Scientific DescriptionSIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model[1].
- SMILESO=C(NC1=C(F)C=CC=C1C)C2=C(NC3CCC3)N=C(NC4=CC=C(N5CCN(C)CC5)C(F)=C4)N=C2
- UNSPSC12131703