Silybin B [142797-34-0]

MedChem Express

Silybin B [142797-34-0]

10

142797-34-0

Research Use Only

99.90

C25H22O10

482.44

Silybin B (Silibinin B) is an orally active amyloid-beta aggregation inhibitor and ATR pathway activator, that can cross the blood-brain barrier. Silybin B inhibits Abeta fibril formation and promotes amorphous aggregate formation, while activating the ATR-mediated DNA damage repair pathway and inhibiting JNK/p38 MAPK signaling. Silybin B can reduce Cisplatin (HY-17394)-induced neuronal DNA damage and apoptosis. Silybin B has anti-oxidative stress, cell cycle regulation and neuroprotective activities. Silybin B is mainly used in the study of Alzheimers disease and Cisplatin chemotherapy-related neurotoxicity[1][2][3].

O=C1[C@H](O)[C@@H](C2=CC=C(O[C@@H](CO)[C@H](C3=CC=C(O)C(OC)=C3)O4)C4=C2)OC5=CC(O)=CC(O)=C15

-20°C,2°C to 8°C

12352200