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Simeprevir (sodium)

HY-10241A
MedChem Express
CAS Number1241946-89-3
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Simeprevir (sodium) [1241946-89-3]
  • Delivery Days Customer
    10
  • CAS Number
    1241946-89-3
  • Certification
    Research Use Only
  • Molecular Formula
    C38H47N5O7S2.xNa
  • Scientific Description
    Simeprevir (TMC435; TMC435350) sodium is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K i of 0.36 nM. Simeprevir sodium inhibits HCV replication with an EC 50 of 7.8 nM. Simeprevir sodium also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir sodium inhibits the main protease (M pro ) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses [1] [4] .
  • SMILES
    O=S(NC([C@]12[C@@](/C=C\CCCCN(C([C@@]3([H])[C@](C[C@H](C3)OC4=CC(C5=NC(C(C)C)=CS5)=NC6=C4C=CC(OC)=C6C)([H])C(N2)=O)=O)C)([H])C1)=O)(C7CC7)=O.[Na].[x]
  • UNSPSC
    12352200