Simeprevir (sodium) [1241946-89-3]

MedChem Express

Simeprevir (sodium) [1241946-89-3]

10

1241946-89-3

Research Use Only

h302-h315-h319-h335,p261-p264-p270-p271-p280-p302+p352-p304+p340-p305+p351+p338-p330-p362+p364-p403+p233-p405-p501

C38H47N5O7S2.xNa

Simeprevir (TMC435; TMC435350) sodium is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir sodium inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir sodium also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir sodium inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses[1][4].

O=S(NC([C@]12[C@@](/C=C\CCCCN(C([C@@]3([H])[C@](C[C@H](C3)OC4=CC(C5=NC(C(C)C)=CS5)=NC6=C4C=CC(OC)=C6C)([H])C(N2)=O)=O)C)([H])C1)=O)(C7CC7)=O.[Na].[x]

12352200