Simmiparib [1551355-46-4]
HY-115552
CAS Number1551355-46-4
Product group Chemicals
Estimated Purity99.01
Molecular Weight486.42
Overview
- SupplierMedChem Express
- Product NameSimmiparib [1551355-46-4]
- Delivery Days Customer10
- CAS Number1551355-46-4
- CertificationResearch Use Only
- Estimated Purity99.01
- Molecular FormulaC23H18F4N6O2
- Molecular Weight486.42
- Scientific DescriptionSimmiparib is a highly potent and orally active PARP1 and PARP2 inhibitor with IC50 values of 1.75 nM and 0.22 nM, respectively. Simmiparib has more potent PARP1/2 inhibition than its parent Olaparib (HY-10162). Simmiparib induces DNA double-strand breaks (DSB) accumulation and G2/M arrest in homologous recombination repair (HR)-deficient cells, thereby inducing apoptosis. Simmiparib exhibits remarkable anticancer activities in cells and nude mice bearing xenografts[1].
- SMILESO=C1NN=C(CC2=CC=C(F)C(C(N3CC4=NN=C(C(F)(F)F)N4C(C)C3)=O)=C2)C5=C1C=CC=C5
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352200