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Simufilam (dihydrochloride)

HY-139142A
MedChem Express
CAS Number2480226-06-8
Product group Chemicals
Molecular Weight332.27
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Simufilam (dihydrochloride) [2480226-06-8]
  • Delivery Days Customer
    10
  • CAS Number
    2480226-06-8
  • Certification
    Research Use Only
  • Molecular Formula
    C15H23Cl2N3O
  • Molecular Weight
    332.27
  • Scientific Description
    Simufilam dihydrochloride (PTI-125 dihydrochloride) is an orally active FLNA modulator. Simufilam dihydrochloride restores NMDAR signaling and Arc expression. Simufilam dihydrochloride inhibits overactive mTOR signaling by restoring the normal conformation of FLNA, improves insulin sensitivity, reduces Abeta42-induced neuroinflammation and tau protein hyperphosphorylation. Simufilam dihydrochloride can be used for research of Alzheimers disease[1][2][3].
  • SMILES
    O=C1N(CC2=CC=CC=C2)C3(CCN(C)CC3)NC1.[H]Cl.[H]Cl
  • UNSPSC
    12352200

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