Simvastatin acid-d6 (ammonium)

MedChem Express

Simvastatin acid-d6 (ammonium)

10

Research Use Only

C25H37D6NO6

459.65

Simvastatin acid-d6 (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1].

O=C(C[C@@H](C[C@@H](CC[C@@]1([H])[C@H](C=CC2=C[C@@H](C[C@@H]([C@]12[H])OC(C(CC)(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)C)C)O)O)[O-].[NH4+]

12352200