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SIN1 Antibody

Research Use Only
ORB248120
Biorbyt
ApplicationsWestern Blot
Product group Antibodies
ReactivityCanine, Human, Mouse, Rat
TargetMAPKAP1
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Overview

  • Supplier
    Biorbyt
  • Product Name
    SIN1 Antibody
  • Delivery Days Customer
    16
  • Application Supplier Note
    Provided assay concentrations are suggestions only, SIN1 antibody titration may be required for optimal results.
  • Applications
    Western Blot
  • Applications Supplier
    Western blot: 1-3ug/ml WB
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID79109
  • Target name
    MAPKAP1
  • Target description
    MAPK associated protein 1
  • Target synonyms
    JC310; MEKK2-interacting protein 1; MIP1; mitogen-activated protein kinase 2-associated protein 1; mitogen-activated protein kinase associated protein 1; mSIN1; ras inhibitor MGC2745; SAPK-interacting protein 1; SIN1; SIN1b; SIN1g; stress-activated map kinase interacting protein 1; stress-activated protein kinase-interacting 1; target of rapamycin complex 2 subunit MAPKAP1; TORC2 subunit MAPKAP1
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    mTOR, or Mammalian target of rapamycin, a large protein kinase, is a regulator of cell growth and survival via its mTORC1 (mTOR + GBL + Raptor) and mTORC2 (mTOR + GBL + SIN1 + Rictor) complexes. SIN1 is an essential component of mTORC2, which activates Akt by phosphorylating Ser473. Phosphorylation of SIN1 at Thr86/398 causes its dissociation from the mTORC2 complex, inhibiting mTORC2s kinase activity.
  • Reactivity
    Canine, Human, Mouse, Rat
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203