SIN1 Antibody

Biorbyt

SIN1 Antibody

10

Provided assay concentrations are suggestions only, SIN1 antibody titration may be required for optimal results.

Western Blot

Western blot: 1-3ug/ml WB

Research Use Only

Polyclonal

Unconjugated

MAPKAP1

MAPK associated protein 1

JC310, MIP1, SIN1, SIN1b, SIN1g, target of rapamycin complex 2 subunit MAPKAP1, MEKK2-interacting protein 1, SAPK-interacting protein 1, TORC2 subunit MAPKAP1, mSIN1, mitogen-activated protein kinase 2-associated protein 1, mitogen-activated protein kinase associated protein 1, ras inhibitor MGC2745, stress-activated map kinase interacting protein 1, stress-activated protein kinase-interacting 1

Rabbit

IgG

mTOR, or Mammalian target of rapamycin, a large protein kinase, is a regulator of cell growth and survival via its mTORC1 (mTOR + GBL + Raptor) and mTORC2 (mTOR + GBL + SIN1 + Rictor) complexes. SIN1 is an essential component of mTORC2, which activates Akt by phosphorylating Ser473. Phosphorylation of SIN1 at Thr86/398 causes its dissociation from the mTORC2 complex, inhibiting mTORC2s kinase activity.

Canine, Human, Mouse, Rat

-20°C,2°C to 8°C

12352203