SIPA1L1 antibody

GeneTex

SIPA1L1 antibody

9

WB: 0.5 - 1 microg/mL. IHC-P: 5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

SIPA1L1

signal induced proliferation associated 1 like 1

E6TP1; high-risk human papilloma viruses E6 oncoproteins targeted protein 1; signal-induced proliferation-associated 1-like protein 1; SIPA1-like protein 1; SPAR1; spine-associated RapGAP 1

Rabbit

IgG

Signal-induced proliferation-associated 1-like protein 1

Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.

-20°C or -80°C,2°C to 8°C

12352203