Sipeimine

MedChem Express

Sipeimine [61825-98-7]

10

61825-98-7

Research Use Only

98.0

C27H43NO3

429.64

Sipeimine (Imperialine) is an inhibitor targeting the PI3K/AKT/NF-kappaB pathway and NLRP3 inflammasome, which can competitively bind to PI3K and p65. Sipeimine inhibits PI3K/AKT phosphorylation, blocks NF-kappaB nuclear translocation and NLRP3 inflammasome activation. Sipeimine exerts anti-inflammatory activities, inhibits pyroptosis and ferroptosis, and protects the extracellular matrix. Sipeimine can reduce cartilage degradation and synovial inflammation in osteoarthritis and improve PM2.5-induced lung injury. Sipeimine is mainly used in the study of anti-inflammatory and degenerative diseases[1][2].

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-20°C,2°C to 8°C

12352200