Sipholenone A [78518-74-8]

AdipoGen Life Sciences

Sipholenone A

10

78518-74-8

Research Use Only

>98%

C30H50O4

474.7

Chemical. CAS: 78518-74-8. Formula: C30H50O4. MW: 474.7. Isolated from marine sponge Siphonochalina siphonella. Efficient inhibitor of P-glycoprotein (Pgp, MDR-1) function through direct interactions. By inhibiting MDR-1, active compounds remain in the cytoplasm longer and allowing them to be more effective within the cell. Reversing agent for the treatment of multidrug resistance (MDR) in Pgp-overexpressing tumors. Potentiates the cytotoxicity of established P-gp substrates such as colchicine, vinblastine and paclitaxel. Antiproliferative, antiangiogenic and cytotoxic compound. Moderate antifouling compound. - Efficient inhibitor of P-glycoprotein (Pgp, MDR-1) function through direct interactions. By inhibiting MDR-1, active compounds remain in the cytoplasm longer and allowing them to be more effective within the cell. Reversing agent for the treatment of multidrug resistance (MDR) in Pgp-overexpressing tumors. Potentiates the cytotoxicity of established Pgp substrates such as colchicine, vinblastine and paclitaxel. Antiproliferative, antiangiogenic and cytotoxic compound. Moderate antifouling compound.

CC(O1)(C)C(CC[C@@]2(C)[C@@]1([H])CC[C@@](O)(C)[C@@H]2CC[C@@H]3C(C)(C)[C@@](CC[C@@]4(C)O)([H])[C@@]4([H])CC=C3C)=O

-20°C,2°C to 8°C

12352200