SIRT2 Antibody

Biorbyt

SIRT2 Antibody

10

Optimal dilution of the Sirtuin 2 antibody should be determined by the researcher.

Flow cytometry: 1-2ug/million cells,Immunofluorescence: 1-2ug/ml,Western blot: 1-2ug/ml FACS, IF, WB

Research Use Only

Monoclonal

PCRP-SIRT2-1A8

Unconjugated

SIRT2

sirtuin 2

SIR2, SIR2L, SIR2L2, NAD-dependent protein deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-2, NAD-dependent protein defatty-acylase sirtuin-2, SIR2-like protein 2, regulatory protein SIR2 homolog 2, silent information regulator 2, sir2-related protein type 2, sirtuin type 2

Mouse

IgG1

NAD-dependent protein deacetylase sirtuin-2

The silent information regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. In S. cerevisiae, Sir2p deacetylates histones in a NAD-dependent manner, which regulates silencing at the telomeric, rDNA and silent mating-type loci. Sir2p is the founding member of a large family, designated sirtuins, which contain a conserved catalytic domain. The human homologs, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT proteins may function via mono-ADP-ribosylation of proteins. SIRT2 contains a 323 amino acid catalytic core domain with a NAD-binding domain and a large groove which is the likely site of catalysis.

Human

-20°C,2°C to 8°C

12352203