SJFdelta

Biorbyt

SJFdelta

10

2254609-23-7

Research Use Only

98.00%

C62H63F2N7O12S

1168.27

SJFdelta is a 10-atom linker PROTAC that selectively degrades p38delta with a DC50 of 46.17 nM, without degrading p38alpha, p38beta, or p38gamma[1].

C(NC1=CC(F)=C(OC=2C3=C(C=C(OCCOCCOCCOC4=C(CNC(=O)[C@H]5N(C([C@H](C(C)C)N6CC=7C(C6=O)=CC=CC7)=O)C[C@H](O)C5)C=CC(=C4)C=8SC=NC8C)C(OC)=C3)N=CC2)C=C1)(=O)C9(C(NC%10=CC=C(F)C=C%10)=O)CC9

-20°C

12352200