SKF-83566 [99295-33-7]

MedChem Express

SKF-83566 [99295-33-7]

9

99295-33-7

Research Use Only

99.86

C17H18BrNO

332.23

SKF-83566 is a potent,?blood-brain permeable and orally active D1-like dopamine receptor (D1DR)?antagonist and a weaker competitive antagonist at the vascular 5-HT2?receptor (Ki=11 nM)[1][3]. SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC50?of 5.7 microM[2]. SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC1 and AC5 in the isolated rabbit thoracic aorta[4]. SKF-83566 can be used for research of parkinsons disease and nicotine craving alleviation[5].

OC1=C(Br)C=C2CCN(C)CC(C3=CC=CC=C3)C2=C1

-20°C,2°C to 8°C

12352200