SKF-83566

MedChem Express

SKF-83566 [99295-33-7]

9

99295-33-7

Research Use Only

99.86

C17H18BrNO

332.23

SKF-83566 is a potent,?blood-brain permeable and orally active D1-like dopamine receptor (D1DR) ?antagonist and a weaker competitive antagonist at the vascular 5-HT 2 ?receptor ( K i =11 nM) [1] [3] . SKF-83566 is a competitive DAT (dopamine transporter) inhibitor with an IC 50 ?of 5.7 microM [2] . SKF-83566 also shows selective inhibition for adenylyl cyclase 2 (AC2) over AC 1 and AC 5 in the isolated rabbit thoracic aorta [4] . SKF-83566 can be used for research of parkinsons disease and nicotine craving alleviation [5] .

OC1=C(Br)C=C2CCN(C)CC(C3=CC=CC=C3)C2=C1

-20°C,2°C to 8°C

12352200