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SKF-86002 (dihydrochloride)

HY-108641
MedChem Express
CAS Number116339-68-5
DownloadMSDS
Product group Chemicals
Molecular Weight370.27
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Overview

  • Supplier
    MedChem Express
  • Product Name
    SKF-86002 (dihydrochloride) [116339-68-5]
  • Delivery Days Customer
    10
  • CAS Number
    116339-68-5
  • Certification
    Research Use Only
  • Molecular Formula
    C16H14Cl2FN3S
  • Molecular Weight
    370.27
  • Scientific Description
    SKF-86002 dihydrochloride is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 dihydrochloride inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-alpha production (IC 50 = 1 microM). SKF-86002 dihydrochloride inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid [1] [2] [3] .
  • SMILES
    [H]Cl.FC1=CC=C(C2=C(C3=CC=NC=C3)N4C(SCC4)=N2)C=C1.[H]Cl
  • UNSPSC
    12352200