SKP2-C25 --- Skp2 Inhibitor [222716-34-9] [222716-34-9]
BS-60136C
CAS Number222716-34-9
Product group Chemicals
Estimated Purity98 - 98.0
Molecular Weight420.52
Overview
- SupplierBioss
- Product NameSKP2-C25 --- Skp2 Inhibitor [222716-34-9] [222716-34-9]
- Delivery Days Customer16
- CAS Number222716-34-9
- CertificationResearch Use Only
- ConjugateUnconjugated
- Estimated Purity98 - 98.0
- Molecular FormulaC24 H24 N2 O3 S
- Molecular Weight420.52
- Scientific DescriptionSKP2-C25 is a potent, selective and cell permeable Skp2 inhibitor. It selectively inhibits Skp2 E3 ligase activity, but not activity of other SCF complexes. It also phenocopies the effects observed upon genetic Skp2 deficiency, such as suppressing survival and Akt-mediated glycolysis and triggering p53-independent cellular senescence. SKP2-C25 exhibits potent antitumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival. It is a useful chemical probe to target Skp2, which is a promising target for restricting cancer stem cell and cancer progression.
- SMILESCCC1C=C2C(=O)C(=COC2=C(CN2CCCCC2)C=1O)C1=NC2C=CC=CC=2S1
- Storage Instruction-20°C
- UNSPSC12161509