SLU-PP-332 [303760-60-3]

AdipoGen Life Sciences

SLU-PP-332 [303760-60-3]

10

303760-60-3

Research Use Only

>98%

C18H14N2O2

290.3

Chemical. CAS: 303760-60-3. Formula: C18H14N2O2. MW: 290.3. SLU-PP-332 is a potent and selective pan-estrogen-related receptor (ERR) agonist (EC50 values are 98 nM, 230 nM and 430 nM for ERRalpha, ERRbeta and ERRgamma respectively). SLU-PP-332 increases energy expenditure and fatty acid oxidation, decreases fat mass, and improves insulin sensitivity. It enhances mitochondrial function and cellular respiration in skeletal muscle cell lines. SLU-PP-332 decreases body weight and fat mass, blood levels of total cholesterol, HDL and triglycerides and adipocyte size in a mouse model of high-fat diet-induced obesity when administered at a dose of 50 mg/kg twice per day. It reduces blood glucose levels in a glucose tolerance test in the same animals at the same dose. Estrogen-related receptors ERRalpha and ERRgamma are essential regulators of cardiac metabolism. SLU-PP-332 significantly improved ejection fraction, ameliorated fibrosis and increased survival associated with pressure overload-induced heart failure (HF) without affecting cardiac hypertrophy. - SLU-PP-332 is a potent and selective pan-estrogen-related receptor (ERR) agonist (EC50 values are 98 nM, 230 nM and 430 nM for ERRalpha, ERRbeta and ERRgamma respectively). SLU-PP-332 increases energy expenditure and fatty acid oxidation, decreases fat mass, and improves insulin sensitivity. It enhances mitochondrial function and cellular respiration in skeletal muscle cell lines. SLU-PP-332 decreases body weight and fat mass, blood levels of total cholesterol, HDL and triglycerides and adipocyte size in a mouse model of high-fat diet-induced obesity when administered at a dose of 50 mg/kg twice per day. It reduces blood glucose levels in a glucose tolerance test in the same animals at the same dose. Estrogen-related receptors ERRalpha and ERRgamma are essential regulators of cardiac metabolism. SLU-PP-332 significantly improved ejection fraction, ameliorated fibrosis and increased survival associated with pressure overload-induced heart failure (HF) without affecting cardiac hypertrophy.

O=C(C1=CC=C(O)C=C1)N/N=C/C2=CC3=CC=CC=C3C=C2

-20°C,2°C to 8°C

12352200