SLW131

MedChem Express

SLW131

5

Research Use Only

C21H27N5O5S

461.53

SLW131 (Compound 10) is the antagonist for CCR7 with a good affinity of Ki of 9.85 nM. SLW131 inhibits CCL19-induced Go protein activation with an IC50 of 29.4 microM, inhibits beta-arrestin2 recruitment with an IC50 of 6.0 microM. SLW131 inhibits CCL19-induced cell morphological changes in primary BMDCs, and CCR7-mediated migration in mouse CD4+ T cell[1].

O=C(C1=CC=CC(NC(C(N[C@H](C(C)(C)C)C2=CC=C(O2)C)=N3)=NS3(=O)=O)=C1O)N(C)C

12352200