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Immunohistochemistry of paraffin-embedded Human liver carcinoma tissue using Smad3 Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Human liver carcinoma tissue using Smad3 Monoclonal Antibody at dilution of 1:200.
Immunohistochemistry of paraffin-embedded Human liver carcinoma tissue using Smad3 Monoclonal Antibody at dilution of 1:200.

SMAD3 Monoclonal Antibody

Research Use Only
E-AB-22241
Elabscience
Product group Antibodies
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More than 130 suppliers
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Overview

  • Supplier
    Elabscience
  • Product Name
    SMAD3 Monoclonal Antibody
  • Delivery Days Customer
    12
  • Certification
    Research Use Only
  • Scientific Description
    Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
  • UNSPSC
    12352203