SML-10-70-1 [1536470-98-0]

MedChem Express

SML-10-70-1 [1536470-98-0]

9

1536470-98-0

Research Use Only

C25H42ClN7O13P2

746.04

SML-10-70-1 is a ligand for RAS, which covalently modifies the K-Ras G12C mutant protein, and inhibits the phosphorylation of ERK and Akt. SML-10-70-1 inhibits the proliferation of cancer cells H23, H358 and A549 with IC50 of 26.6-47.6 microM[1].

O=C1C(N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OCCNC(CCl)=O)(N[C@@H](C)C(OCC(CCC)CCC)=O)=O)(O)=O)O3)=C2N=C(N)N1

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