SMN1 antibody [2F1]

GeneTex

SMN1 antibody [2F1]

9

WB: 1/500 - 1/2000. IHC-P: 1/200 - 1/1000. FACS: 1/200 - 1/400. ELISA: 1/10000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Flow Cytometry, Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

2F1

Unconjugated

SMN1

survival of motor neuron 1, telomeric

BCD541; component of gems 1; GEMIN1; gemin-1; SMA; SMA@; SMA1; SMA2; SMA3; SMA4; SMN; SMNT; survival motor neuron 1 protein; survival motor neuron protein; T-BCD541; TDRD16A; tudor domain containing 16A

Mouse

IgG1

Survival motor neuron protein

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy; mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve t

Human, Monkey

-20°C or -80°C,2°C to 8°C

12352203