SMS2-IN-1

Biorbyt

SMS2-IN-1

10

2098890-15-2

Research Use Only

C34H37F6N3O5

681.67

SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC50 of 6.5 nM and a Kd of 37 nM. SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 (IC50 of 1000 nM).

C1(C)(CC1)OC(N1CCC(CCCOC2=C(C(N(CC3C=C(C(F)(F)F)C=C(C(F)(F)F)C=3)C)=O)C(=O)N(C)C3C2=CC=CC=3)CC1)=O

12352200