SMU-B [1253286-90-6]
HY-120387
CAS Number1253286-90-6
Product group Chemicals
Molecular Weight515.41
Overview
- SupplierMedChem Express
- Product NameSMU-B [1253286-90-6]
- Delivery Days Customer5
- CAS Number1253286-90-6
- CertificationResearch Use Only
- Molecular FormulaC26H25Cl2FN4O2
- Molecular Weight515.41
- Scientific DescriptionSMU-B is the orally active inhibitor for ALK (IC50c-ros oncogene 1 (ROS1), c-MET (IC50=1.87 nM) and AXL (IC50=28.9 nM). SMU-B inhibits the proliferation of MKN45, H1993 and H441 with IC50s of 0.02 microM, 1.58 microM and 2.82 microM, respectively. SMU-B exhibits antitumor efficacy in mouse models[1][2].
- SMILESO=C1NC2=C(C=CC(C3=CC(O[C@@H](C4=C(Cl)C=CC(F)=C4Cl)C)=C(N)N=C3)=C2)C15CCN(C)CC5
- UNSPSC12352200