SMURF2 Antibody, HRP conjugated

Cusabio

SMURF2 Antibody, HRP conjugated

20

ELISA

Research Use Only

Polyclonal

HRP

SMURF2

SMAD specific E3 ubiquitin protein ligase 2

E3 ubiquitin-protein ligase SMURF2, E3 ubiquitin ligase SMURF2, HECT-type E3 ubiquitin transferase SMURF2, SMAD ubiquitination regulatory factor 2, hSMURF2

Rabbit

IgG

E3 ubiquitin-protein ligase SMURF2

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.

Human

-20°C or -80°C

41116161