sn-Glycero-3-phosphocholine [28319-77-9]

TargetMol Chemicals

sn-Glycero-3-phosphocholine [28319-77-9]

4

28319-77-9

Chemical

Research Use Only

sn-Glycero-3-phosphocholine

98.53%

C8H20NO6P

257.22

sn-Glycero-3-phosphocholine (Choline glycerophosphate) is a natural choline compound found in the brain and in milk. It is also a parasympathomimetic acetylcholine precursor which may have a potential for the treatment of Alzheimers disease and dementia. sn-Glycero-3-phosphocholine rapidly delivers choline to the brain across the blood-brain barrier and is a biosynthetic precursor of the acetylcholine neurotransmitter. It is a non-prescription drug in most countries due to its Generally Recognised As Safe (GRAS) status [1]. Studies have investigated its efficacy for cognitive disorders including stroke and Alzheimers disease. An Italian multicentre clinical trial on 2, 044 patients suffering from recent stroke were supplied Glycerylphosphorylcholine in doses of 1, 000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. The trial confirmed the therapeutic role of alpha-GPC on the cognitive recovery of patients based on four measurement scales, three of which reached statistical significance [2].

3 years

P(OC[C@@H](CO)O)(OCC[N+](C)(C)C)(=O)[O-]

-20°C

12352200