SNAP 94847

MedChem Express

SNAP 94847 [487051-12-7]

10

487051-12-7

Research Use Only

C29H32F2N2O2

478.57

SNAP 94847 is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with ( K i = 2.2 nM, K d =530 pM), it displays >80-fold and >500-fold selectivity over? MCHalpha1A ?and MCHD2 ?receptors respectively. SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters [1] [3] .

CC1=CC=C(NC(C(C)C)=O)C=C1C2CCN(CC3=CC=C(OC4=CC(F)=C(F)C=C4)C=C3)CC2

12352200