SNX-2112 [908112-43-6]

MedChem Express

SNX-2112 [908112-43-6]

14

908112-43-6

Research Use Only

99.41

C23H27F3N4O3

464.48

SNX-2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a Kd of 16 nM for Hsp90 and IC50s of 30 nM, 30 nM for Hsp90 alpha and Hsp90 beta, also induces Her-2 degradation, and inhibits Grp94 and Trap-1, with IC50s of 10?nM, 4.275 microM and 0.862 microM, respectively[1]. SNX-2112 (PF 04928473) binds Hsp90 isoforms Hsp90alpha, Hsp90beta and Hsp90b1/Grp94 with Kds of 4 nM, 6 nM and 484 nM, respectively[2].

FC(F)(C1=NN(C2=CC(N[C@@H]3CC[C@H](CC3)O)=C(C=C2)C(N)=O)C(CC(C)(C4)C)=C1C4=O)F

-20°C,2°C to 8°C

12352200