SON antibody
GTX129778
ApplicationsImmunoFluorescence, ImmunoCytoChemistry
Product group Antibodies
TargetSON
Overview
- SupplierGeneTex
- Product NameSON antibody
- Delivery Days Customer9
- Application Supplier NoteICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID6651
- Target nameSON
- Target descriptionSON DNA and RNA binding protein
- Target synonymsBASS1, C21orf50, DBP-5, NREBP, SON3, TOKIMS, protein SON, Bax antagonist selected in Saccharomyces 1, NRE-binding protein, SON DNA binding protein, negative regulatory element-binding protein
- HostRabbit
- IsotypeIgG
- Protein IDP18583
- Protein NameProtein SON
- Scientific DescriptionThe protein encoded by this gene binds to a specific DNA sequence upstream of the upstream regulatory sequence of the core promoter and second enhancer of human hepatitis B virus (HBV). Through this binding, it represses HBV core promoter activity, transcription of HBV genes, and production of HBV virions. The protein shows sequence similarities with other DNA-binding structural proteins such as gallin, oncoproteins of the MYC family, and the oncoprotein MOS. It may also be involved in protecting cells from apoptosis and in pre-mRNA splicing. Several transcript variants encoding different isoforms have been described for this gene, but the full-length nature of only two of them has been determined. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Xie Y, Gao S, Zhang K, et al. Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly. Cell Rep. 2023,42(8):112988. doi: 10.1016/j.celrep.2023.112988Read this paper
- Gao S, Esparza M, Dehghan I, et al. Nuclear speckle integrity and function require TAO2 kinase. Proc Natl Acad Sci U S A. 2022,119(25):e2206046119. doi: 10.1073/pnas.2206046119Read this paper
- Aksenova V, Smith A, Lee H, et al. Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway. Nat Commun. 2020,11(1):4577. doi: 10.1038/s41467-020-18266-2Read this paper
- Mor A, White A, Zhang K, et al. Influenza virus mRNA trafficking through host nuclear speckles. Nat Microbiol. 2016,1(7):16069. doi: 10.1038/nmicrobiol.2016.69Read this paper
Datasheet
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