Sorafenib tosylate [475207-59-1] [475207-59-1]

Chemodex

Sorafenib tosylate [475207-59-1] [475207-59-1]

10

475207-59-1

Research Use Only

>98%

Danger,Excepted quantity

C21H16ClF3N4O3 . C7H8SO3

637.03

Chemical. CAS: 475207-59-1. Formula: C21H16ClF3N4O3 . C7H8SO3. MW: 637.03. Sorafenib tysolate is a multi-kinase inhibitor that inhibits Raf-1 and B-RAF (IC50s = 6n and 22nM, respectively), as well as the receptor tyrosine kinases VEGFR2, VEGFR3, PDGFRbeta, Flt-3, c-Kit, FGFR-1 (Flt-2) and RET, involved in neovascularization and tumor progression. It is selective for these kinases over 12 other kinases, including ERK1, MEK1, EGFR, and HER2 (IC50s = >10microM for all). Sorafenib tosylate exerts broad-spectrum anticancer activity and disrupts signaling pathways that are vital for tumor growth and angiogenesis. - Sorafenib tysolate is a multi-kinase inhibitor that inhibits Raf-1 and B-RAF (IC50s = 6n and 22nM, respectively), as well as the receptor tyrosine kinases VEGFR2, VEGFR3, PDGFRbeta, Flt-3, c-Kit, FGFR-1 (Flt-2) and RET, involved in neovascularization and tumor progression. It is selective for these kinases over 12 other kinases, including ERK1, MEK1, EGFR, and HER2 (IC50s = >10microM for all). Sorafenib tosylate exerts broad-spectrum anticancer activity and disrupts signaling pathways that are vital for tumor growth and angiogenesis.

ClC1=C(C(F)(F)F)C=C(NC(NC2=CC=C(OC3=CC(C(NC)=O)=NC=C3)C=C2)=O)C=C1.CC4=CC=C(S(=O)(O)=O)C=C4

2°C to 8°C,RT

UN3077

12352200