Sorafenib (tosylate)

MedChem Express

Sorafenib (Tosylate) [475207-59-1]

10

475207-59-1

Research Use Only

99.91

C28H24ClF3N4O6S

637.03

Sorafenib tosylate (Bay 43-9006 tosylate) is a potent and orally active Raf inhibitor with IC 50 s of 6 nM and 20 nM for Raf-1 and B-Raf , respectively. Sorafenib tosylate is a multikinase inhibitor with IC 50 s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2 , VEGFR3 , PDGFRbeta , FLT3 and c-Kit , respectively. Sorafenib tosylate induces autophagy and apoptosis . Sorafenib tosylate has anti-tumor activity. Sorafenib tosylate is a ferroptosis activator [1] .

O=S(C1=CC=C(C=C1)C)(O)=O.O=C(NC2=CC=C(C(C(F)(F)F)=C2)Cl)NC3=CC=C(OC4=CC(C(NC)=O)=NC=C4)C=C3

2°C to 8°C

12352200