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SOX2 antibody

GTX101506
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
TargetSOX2
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Overview

  • Supplier
    GeneTex
  • Product Name
    SOX2 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-Fr: 1:100-1:1000. FACS: 1:50-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID6657
  • Target name
    SOX2
  • Target description
    SRY-box transcription factor 2
  • Target synonyms
    ANOP3, MCOPS3, transcription factor SOX-2, SRY (sex determining region Y)-box 2, SRY-box 2, SRY-related HMG-box gene 2, sex determining region Y-box 2, transcription factor SOX2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP48431
  • Protein Name
    Transcription factor SOX-2
  • Scientific Description
    This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Chu PY, Huang WC, Tung SL, et al. IFITM3 promotes malignant progression, cancer stemness and chemoresistance of gastric cancer by targeting MET/AKT/FOXO3/c-MYC axis. Cell Biosci. 2022,12(1):124. doi: 10.1186/s13578-022-00858-8
    Read this paper
  • Erni ST, Gill JC, Palaferri C, et al. Hair Cell Generation in Cochlear Culture Models Mediated by Novel γ-Secretase Inhibitors. Front Cell Dev Biol. 2021,9:710159. doi: 10.3389/fcell.2021.710159
    Read this paper
  • Yan Z, Cheng M, Hu G, et al. Positive feedback of SuFu negating protein 1 on Hedgehog signaling promotes colorectal tumor growth. Cell Death Dis. 2021,12(2):199. doi: 10.1038/s41419-021-03487-0
    Read this paper
  • Chiu YF, Wu CC, Kuo MH, et al. Critical role of SOX2-IGF2 signaling in aggressiveness of bladder cancer. Sci Rep. 2020,10(1):8261. doi: 10.1038/s41598-020-65006-z
    Read this paper
  • Lee CJ, Sung PL, Kuo MH, et al. Crosstalk between SOX2 and cytokine signaling in endometrial carcinoma. Sci Rep. 2018,8(1):17550. doi: 10.1038/s41598-018-35592-0
    Read this paper
  • Pérez Saturnino A, Lust K, Wittbrodt J. Notch signalling patterns retinal composition by regulating atoh7 during post-embryonic growth. Development. 2018,145(21). doi: 10.1242/dev.169698
    Read this paper
  • Lust K, Wittbrodt J. Activating the regenerative potential of Müller glia cells in a regeneration-deficient retina. Elife. 2018,7. doi: 10.7554/eLife.32319
    Read this paper
  • Uribe-Etxebarria V, Luzuriaga J, García-Gallastegui P, et al. Notch/Wnt cross-signalling regulates stemness of dental pulp stem cells through expression of neural crest and core pluripotency factors. Eur Cell Mater. 2017,34:249-270. doi: 10.22203/eCM.v034a16
    Read this paper
  • Seleit A, Krämer I, Riebesehl BF, et al. Neural stem cells induce the formation of their physical niche during organogenesis. Elife. 2017,6:pii: e29173. doi: 10.7554/eLife.29173.
    Read this paper

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Figure 1. Western blot analysis of SOX2 using anti-SOX2 antibody (A00105-1). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample under reducing conditions. Lane 1: human U251 whole cell lysates, Lane 2: human 293T whole cell lysates, Lane 3: rat PC-12 whole cell lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 ma for 50-90 minutes. Blocked the membrane with 5% non-fat milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-SOX2 antigen affinity purified poly clonal antibody (Catalog # A00105-1) at 0.5 microg/ml overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit ING-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Luminescence detection (ECL) kit (Catalog # EK1002) with Anon 5200 system. A specific band was detected for SOX2 at approximately 36 kDa. The expected band size for SOX2 is at 34 kDa.
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