Sp-2-Cl-cAMPS [124854-63-3]

TargetMol Chemicals

Sp-2-Cl-cAMPS [124854-63-3]

9

Research Use Only

C10H11ClN5O5PS

379.72

Sp-2-Cl-cAMPS serves as an agonist for PKA, boasting enhanced membrane permeability and stability against phosphodiesterases. This compound exhibits antimalarial activity, inhibiting the proliferation of the malaria parasite Plasmodium falciparum with an EC50 of 4 microM. Furthermore, Sp-2-Cl-cAMPS binds to the purified regulatory subunit of PfPKA (PfPKAr) with a Ki of 1.3 microM.

NC1=C2C(N(C=N2)[C@H]3[C@H](O)[C@]4([C@](O3)(COP(=O)(S)O4)[H])[H])=NC(Cl)=N1

-20°C

12352200