SPA0355

MedChem Express

SPA0355

5

Research Use Only

C22H21N3O2S

391.49

SPA0355 is a thiourea derivative that has antioxidant and anti-inflammatory properties. SPA0355 inhibits the RANKL (receptor activator of nuclear factor kappaB ligand) induced osteoclast formation in primary bone marrow-derived macrophages. SPA0355 also suppresses the activation of the MAPKs, Akt, and NF-kappaB pathways. Additionally, SPA0355 promotes osteoblast differentiation, increases alkaline phosphatase activity, and enhances mineral nodule formation. SPA0355 can protect ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it useful for studying postmenopausal osteoporosis[1].

S=C(NC)NC1=CC=C(C=C1)OCCN2C3=C(OC4=C2C=CC=C4)C=CC=C3

12352200