SPC-180002 [2170274-53-8]

TargetMol Chemicals

SPC-180002 [2170274-53-8]

72

Research Use Only

SPC-180002

C18H23NO4

317.38

SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 microM for SIRT1 and SIRT3, respectively. It disrupts redox homeostasis through ROS generation, consequently enhancing p21 protein stability and inducing mitochondrial dysfunction. Furthermore, this compound significantly impedes cell cycle progression and malignancy proliferation, while also activating the Nrf2 signaling pathway [1].

3 years

N(CC(C(OC)=O)=C)(CC(C(OC)=O)=C)CCC1=CC=CC=C1

-20°C

12352200