SPD-502 (sodium) [205645-02-9]

MedChem Express

SPD-502 (sodium) [205645-02-9]

9

205645-02-9

Research Use Only

C24H27N4NaO7S

538.55

SPD-502 sodium is a novel glutamate antagonist with potential neuroprotective properties, particularly in brain ischemia. It selectively targets the AMPA receptor, showing high affinity (IC50 = 0.043 microM) and competitive inhibition of AMPA-induced effects in rat cortical membranes and cultured mouse cortical neurons. In vivo, SPD-502 sodium effectively blocks AMPA-evoked spike activity in the hippocampus after intravenous administration, significantly increasing the seizure threshold in mice and demonstrating robust protection against ischemia-induced damage to hippocampal neurons in gerbils. These findings suggest SPD-502 sodium may be promising for treating neurodegenerative conditions associated with glutamate excitotoxicity[1].

O=C(C(CCO)O/N=C1C(NC2=C(CN(CC3)C)C3=C(C4=CC=C(S(=O)(N(C)C)=O)C=C4)C=C2\1)=O)O[Na]

12131703