Spectrin antibody [SB-SP1]

GeneTex

Spectrin antibody [SB-SP1]

9

This antibody reacts specifically with the α and β chains of human erythrocyte spectrin.

WB: 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Monoclonal

SB-SP1

Unconjugated

SPTA1

spectrin alpha, erythrocytic 1

alpha-I spectrin; EL2; elliptocytosis 2; erythroid alpha-spectrin; HPP; HS3; spectrin alpha chain, erythrocyte; spectrin alpha chain, erythrocytic 1; SPH3; SPTA

Mouse

IgG1

Spectrin alpha chain, erythrocytic 1

Spectrin is a major constituent of the erythrocyte skeleton accounting for 25% of the total membrane protein and 75% of the cytoskeletal mass. It is associated with the cytoplasmic surface of the membrane by attachment to ankyrin, a peripheral membrane protein. The membrane skeleton influences several cellular properties such as cell shape, restriction of mobility of the integral membrane protein exposed at the cell surface and transmembrane movement of phospholipids and cholesterol. On SDS PAGE gels erythrocyte spectrin appears as two bands referred to as alpha (240kD) and beta (220kD). While the simplest form of spectrin in solution is an alpha-beta heterodimer, spectrin can undergo self-association in various conditions to form a tetramer of alpha2-beta2. In recent years a large number of spectrin-like molecules have been found in non-erythroid cells. These proteins are known by such different names as fodrin, CBP I, calspectin and TW 260/240.

Human

-20°C or -80°C,2°C to 8°C

12352203