SPI-112

MedChem Express

SPI-112

10

1051387-90-6

Research Use Only

98.01

C22H17FN4O5S

468.46

SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC50s of 1 microM, 18.3 microM and 14.5 microM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively[1][2].

O=C(O)C1=CC=CC(N/N=C2C(NC3=C\2C=C(S(=O)(NCC4=CC=C(F)C=C4)=O)C=C3)=O)=C1

2°C to 8°C

12352200