SPP-86

MedChem Express

SPP-86 [1357349-91-7]

10

1357349-91-7

Research Use Only

99.62

C16H15N5

277.32

SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase , with an IC 50 of 8 nM. SPP-86 inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, also inhibits RET-induced estrogen receptoralpha (ERalpha) phosphorylation in MCF7 cells [1] . SPP-86 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

CC(C)N1C2=NC=NC(N)=C2C(C#CC3=CC=CC=C3)=N1

-20°C,2°C to 8°C

12352200