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Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA863937LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA863937LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA863937LA01HU at dilution of 1:100

SPRTN Antibody

CSB-PA863937LA01HU
Cusabio
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
TargetSPRTN
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Overview

  • Supplier
    Cusabio
  • Product Name
    SPRTN Antibody
  • Delivery Days Customer
    20
  • Applications
    ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID83932
  • Target name
    SPRTN
  • Target description
    SprT-like N-terminal domain
  • Target synonyms
    C1orf124; DNA damage protein targeting VCP; DNA damage-targeting VCP (p97) adaptor; DNA-dependent metalloprotease SPRTN; DVC1; PRO4323; spartan; zinc finger RAD18 domain-containing protein
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9H040
  • Protein Name
    SprT-like domain-containing protein Spartan
  • Scientific Description
    Regulator of UV-induced DNA damage response: acts as a reader of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203

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