SPRTN Antibody

Cusabio

SPRTN Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

SPRTN

SprT-like N-terminal domain

C1orf124, DVC1, PRO4323, spartan, DNA-dependent metalloprotease SPRTN, DNA damage protein targeting VCP, DNA damage-targeting VCP (p97) adaptor, zinc finger RAD18 domain-containing protein

Rabbit

IgG

DNA-dependent metalloprotease SPRTN

Regulator of UV-induced DNA damage response: acts as a reader of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.

Human

-20°C or -80°C

41116161