SR-0813

MedChem Express

SR-0813 [2597186-19-9]

5

2597186-19-9

Research Use Only

99.93

C25H32N6O3S

496.62

SR-0813 is a potent and selective ENL/AF9 YEATS domain inhibitor. SR-0813 has IC 50 and EC 50 values of 25 nM and 205 nM for ENL YEATS domain, respectively. SR-0813 has IC 50 and EC 50 values of 311 nM and 76 nM (CETSA) for AF9 YEATS domain, respectively. SR-0813 binds MAP3K19 with over 100-fold lower affinity ( K d =3.5 microM) than ENL YEATS ( K d =30 nM). SR-0813 can be used for the research of acute leukemia [1] .

O=C(C1=CN2C=C(C3=CC(NS(=O)(NCCN4CCCCC4)=O)=CC=C3)N=C2C=C1)NC5CCC5

-20°C,2°C to 8°C

12352200