SR-1114 [2769141-82-2]

MedChem Express

SR-1114 [2769141-82-2]

10

2769141-82-2

Research Use Only

99.04

C39H42N8O11S

830.86

SR-1114 is a PROTAC degrader targeting ENL. SR-1114 degrades ENL in a CRBN-dependent manner and selectively downregulates ENL target genes. SR-1114 can promote the differentiation of acute myeloid leukemia cells. SR-1114 can be used in tumor research. (Pink: ENL ligand (HY-145409); Black: Linker; Blue: E3 Ligand (HY-14658))[1].

O=C(NCCOCCOCCNS(=O)(NC1=CC=CC(C2=CN3C=C(C=CC3=N2)C(NC4CCC4)=O)=C1)=O)COC5=CC=CC6=C5C(N(C6=O)C7CCC(NC7=O)=O)=O

-20°C,2°C to 8°C

12352200